Peter Attia· MD
What rapamycin basically does is sort of occlude the substrate binding channel in mTORC1. And it's basically physically occluding. And depending, probably, we don't... You know, this is somewhat hand -waving, but there's some evidence for this. Probably the size of the substrate. If it's smaller, it might get easier, and it's not occluded. If it's bigger, it's going to get blocked. And so probably the key substrates in the autophagy pathway simply are not as affected because they get into the kinase domain of mTORC1 still.