The optimal dosing schedule for rapamycin (daily vs. weekly vs. every other week) and the required duration of dosing are poorly explored, even in mouse studies.

“what dose ranges are you seeing in the wild so when you did that survey what what was what were you sort of seeing what percentage of the Raa users were on weekly doses versus daily doses versus tri-weekly and what what was the range of the actual dose yeah so I mean I think in a general sense it was kind of all over the place but um by far the majority were once a week and among those the vast majority were 6 milligrams once a week and I think there's some historical reasons for that that sort of you know has what become become popular in the the online sort of community where people talk to each other but where do you think that number comes from so I think it's partly from Janes study so it's close to Joon study which was 5 milligrams once a week of ever alus I think it's also because many of the people the first people to start taking uh rapy off label were patients of Alan Green out of New York and I think that was sort of his standard dose that he put most people on so I could be wrong about that but that's my impression is that's kind of how that became popularized for lack of a better word within the within the community but having said that there are there's a lot of variation around that both in terms of doses that people are taking once a week and then there's a you know fraction of people who are taking rap ayon daily um uh usually one milligram 2 milligrams um sometimes for you know purposes other than purely for aging so people who have uh existing autoimmune disorders sometimes people are taking rapamycin for that but um but in general I would say among the off Lael rapy users the majority are once a week and of those the majority are 6 milligrams um kind of it's kind of a bodal distribution there's a group of people around 3 milligrams as well but lots of variation around that”

“so so the answer is the answer is no and and and honestly I think we probably never will simply because you know the cost of doing those experiments and all the permutations that you could come up with for time that you initiate and and different doses to test uh I just don't think anybody would ever fund that study”

“absent really good biomarkers for some of these Hallmarks of Aging I think we still have a ways to go before we could say the following Ramy is gero protective towards humans and taking Ramy according to protocol X will add years to human life and presumably improve health span”