The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
unless those old mice got rapamycin if they got six weeks of rapamycin uh they were a hundred percent effective at responding to the vaccine so at least for that measure of immune function rapamycin fully restored the immune system back to that of a youthful immune system
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The "high risk" framing here is the right call. I've had three patients ask about rapa this month and none of them grasped the immunosuppression tradeoff until I walked them through it.
The PEARL trial framing in the dossier is the clearest writeup I've seen for a non-specialist. Worth linking from the AMA pages too.
I'm on 6mg/week, year two. Tracking IL-6, fasting glucose, lipids. Happy to share the spreadsheet if Whalespan wants longitudinal user data.
The dosing variance across the advocate camp is staggering. 3mg, 5mg, 8mg, biweekly, weekly… brief is right that "monitor or specialist only" is the responsible read.
i think it was a 2009 science signaling paper from panjang's lab uh something the title has something about hematopoietic stem cells and rapamycin we'll link to it in the show notes for sure okay yeah it's an amazing study but but my favorite experiment there was this experiment where they took young and old mice and they gave them a influenza vaccine and then they waited uh two weeks and then they gave them a leth what would be a lethal dose of influenza if they hadn't got the vaccine and in the old group half the mice either got rapamycin or they got a control right so the first thing that struck me about that experiment was if you look at just the difference between young and old mice who got the vaccine all of the young mice were protected 100 vaccine response i think it was about 65 so two-thirds of the old mice did not have a sufficient response to the vaccine that they were protected against influenza right and i don't know if the numbers are i don't think the numbers are exactly the same in people but there is definitely that same trend where older adults tend to not respond to vaccines as effect as robustly as younger adults unless those old mice got rapamycin if they got six weeks of rapamycin uh they were a hundred percent effective at responding to the vaccine
there was actually a paper I think it was 2009 from pen jangs lab in mice that preceded the the Joan manic paper where they showed that you could treat with Rapa for I think six weeks in that study um and rejuvenate the immune function of a mouse
Rapamycin extends median and maximum lifespan in mice across multiple lab strains and dosing protocols.
Rapamycin will extend human lifespan by 5+ years at standard weekly dosing.
Weekly rapamycin dosing in healthy adults shows favorable safety and immune markers in early observational data.
Chronic low-dose rapamycin imposes an immune trade-off that outweighs the longevity hypothesis for most healthy adults.
mTORC1 inhibition is the mechanistic backbone for rapamycin's healthspan effects in mammals.
The PEARL trial showed an acceptable 48-week safety profile in healthy adults on weekly rapamycin.