High doses of rapamycin in animals may promote immune cancers. — Whalespan
High doses of rapamycin in animals may promote immune cancers.
⚠ High risk
We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
✕NOTSUPPORTED
⚠
High-risk intervention — consult a physician before acting.Drug-drug interactions, dose-dependence, and screening contraindications apply.
“I think what we did in our high dose study is we just pushed it a little too far we pushed it to the point where rapamycin did something probably to the immune system that that allowed these immune cancers to to escape surveillance or become hyper proliferative and again I'm not I'm not a cancer biologist I'm not an immunologist so I don't I don't have a good feel for what the mechanism is I can tell you what the observation is and that's that all of those animals had aggressive hematocrit cancers when they got this 3 months of rapamycin”
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S. HwangMD · internal medicine
1d
The "high risk" framing here is the right call. I've had three patients ask about rapa this month and none of them grasped the immunosuppression tradeoff until I walked them through it.
AC
A. Coleresearcher
18h
The PEARL trial framing in the dossier is the clearest writeup I've seen for a non-specialist. Worth linking from the AMA pages too.
JB
J. Bauerlongevity self-experimenter
3d
I'm on 6mg/week, year two. Tracking IL-6, fasting glucose, lipids. Happy to share the spreadsheet if Whalespan wants longitudinal user data.
EM
E. Munropharmacist
6d
The dosing variance across the advocate camp is staggering. 3mg, 5mg, 8mg, biweekly, weekly… brief is right that "monitor or specialist only" is the responsible read.
“we pushed it to the point where rapamycin did something probably to the immune system that that allowed these immune cancers to to escape surveillance or become hyper proliferative”