Peter Attia· MD
if you talk to joan um um she will tell you that they had unpublished data that rtb 101 at the doses that they were using in this trial um appears to be specific for mtor complex one like rapamycin
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
if you talk to joan um um she will tell you that they had unpublished data that rtb 101 at the doses that they were using in this trial um appears to be specific for mtor complex one like rapamycin
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The "high risk" framing here is the right call. I've had three patients ask about rapa this month and none of them grasped the immunosuppression tradeoff until I walked them through it.
The PEARL trial framing in the dossier is the clearest writeup I've seen for a non-specialist. Worth linking from the AMA pages too.
I'm on 6mg/week, year two. Tracking IL-6, fasting glucose, lipids. Happy to share the spreadsheet if Whalespan wants longitudinal user data.
The dosing variance across the advocate camp is staggering. 3mg, 5mg, 8mg, biweekly, weekly… brief is right that "monitor or specialist only" is the responsible read.
so there was no ever alignment in the the pivotal phase three there there are a couple things about that trial that are worth just mentioning um so one is that ever alus wasn't in there so the failure of that trial absolutely should not be interpreted as a failure of ramyon or rapalogs because there was no rapalog in that trial
Rapamycin extends median and maximum lifespan in mice across multiple lab strains and dosing protocols.
Rapamycin will extend human lifespan by 5+ years at standard weekly dosing.
Weekly rapamycin dosing in healthy adults shows favorable safety and immune markers in early observational data.
Chronic low-dose rapamycin imposes an immune trade-off that outweighs the longevity hypothesis for most healthy adults.
mTORC1 inhibition is the mechanistic backbone for rapamycin's healthspan effects in mammals.
The PEARL trial showed an acceptable 48-week safety profile in healthy adults on weekly rapamycin.