Impaired glucose homeostasis with rapamycin may reflect a shift towards fat metabolism and ketogenesis, potentially contributing to its beneficial effects.

“i think there's at least as much likelihood that what what this really reflects is an underlying change in in metabolism that might actually account for part of the beneficial effects of rapamycin where they shift away from primarily relying on on glucose as the preferred carbon source and switch over to fat metabolism and and maybe even ketogenesis to some extent and when in that context so it's a different physiological metabolic state in that context when you challenge them with a non-physiological amount of glucose they don't respond the same way so i don't know that it's actually a defect in glucose homeostasis i think it may reflect the the test that's done and in some ways it's an artifact of that test that you get a different response which is in the context of you know diabetes would be interpreted as a bad response it might just reflect a different underlying physiological state”