High doses of resveratrol can activate the AMPK/metformin-related pathway, suggesting synergy with metformin.

“what we find actually is that the higher dose is acting on other pathways including the NP kinase metformin Elena pathway activating it so it's synergistic with metformin we don't know that but part of the debate about resveratrol is that if you give cells in culture or mice too much resurect well then it kicks in other pathways and in this case it was activating a MP kinase as well we published that in our first paper in 2016 supplemental that most people haven't read but we knew it was activating IB Connie's at that high dose”