Resveratrol supplementation at 480mg daily for 2 years reduced arterial stiffening in individuals consuming a high-fructose-sweetened diet.

“High fat/sugar diet caused a 40% increase in artery stiffness but was prevented by 480mg of resveratrol in monkeys.”

“But as you know, there was a really sort of compelling primate study in rhesus monkeys. It was like mid-2000s, or 2011, or something like that. [...] Yes, that's right. They gave these rhesus monkeys resveratrol, and I think they started out with a lower dose, like 80 milligrams per kilogram and they went up to, like, 480. [...] Well, this study was... You know, the doses were very doable on humans when you, you know, convert and basically, you know, feeding these monkeys, they're feeding them, like, this terrible high sucrose diet, high sucrose and high fat, and they, like, it caused them to have, like, 40% increased aortic stiffness, but the resveratrol completely ameliorated it, like...”