High salt intake increases serum sodium, which activates an enzyme that converts glucose to fructose in the body, contributing to increased blood pressure and cardiac hypertrophy.

“when you give a high salt diet to animals that the high salt increases the serum sodium and the serum sodium when it goes up it activates an enzyme that converts glucose which is in our blood and in our tissues to fructose and that conversion to fructose is driven by a high salt diet and it's driven by an increase in serum osmolality or increase in serum sodium”