Sarcopenia and osteoporosis are prevalent in individuals over 75, affecting at least 80% of this age group and leading to a significant decline in activity levels.

“when you think about sarcopenia and when you think about osteoporosis which again i just don't think we're talking about how these things impact animals like we don't study any animal including primates in a setting where sarcopenia and osteoporosis are problematic and yet i would ask anyone to consider the entire population that they know over the age of 75 and i would ask you take every person that is alive today that's over 75 and tell me how many of them are not suffering at least some consequence of one or both of those phenomena and if somebody did that analysis i would be shocked if we didn't find at least 80 percent of people over the age of 75 are experiencing this and if you look at the activity just monitor the activity level of people over the once they hit 75 they fall off a cliff so muscle mass dramatically plummets activity levels dramatically plummet it difficult to say which one's feeding which but there's no question that something is happening to our species at about the age of 75 right that is a structural problem”