Peter Attia· MD
if you have an arthritic process you can without having as much numbness and tingling you can have isolated atrophy of the muscles the thenar the thumb muscles here that give us our opposable thumb you can have atrophy that looks like an indentation right there and some people can have that quietly it can be just a very gradual just from the encroachment on that nerve of the bone spurs that grow through the arthritic process