Peter Attia· MD
but he called that the catabolic crisis model
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but he called that the catabolic crisis model
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As we age, like you said, Peter, the worst thing that you can do is stop. You know, and I think about Doug Patton Jones's work, the catabolic crisis model. This isn't a catabolic crisis, but a catabolic crisis model is when you're off the table, you lose muscle mass and strength rapidly over 40 you and that continues per decade.
The key is preventing the decline that leads to a 'catabolic crisis' or the point at which one becomes unable to live independently.
And during this event, the de facto treatment in hospital is you go into bed rest. And we've known for years that, you know, putting people in bed rest, and you can ask any clinician, it's a bad situation. You're not using your muscles. You become instantly sedentary, obviously. It would exacerbate a lot of other issues if you went into bed rest with type 2 diabetes.
So these events...you can appreciate bed rest in a catabolic crisis if you've got a hospital event is, yeah, that's going to be bad. I get that.
And what happens is if you can imagine somebody's...they're already going down because sarcopenia is happening. When they have a disuse event, they bend the curve dramatically. So there's an accelerated rate of muscle loss.
when it's called the catabolic crisis model that was coined by um the late duck Patton Jones and Kirk English but essentially the more insults that older people have with those periods of inactivity um and immobilization they lose the muscle it may not come back and then they lose a little bit more and all of a sudden you reach um a threshold Beyond which you know you can't perform activities of daily living
this kind of event can trigger a downward spiral and a crossing of a disability threshold a point at which physical function has become so severely impaired that it now undermines the daily activities that ordinarily would prevent even greater muscle loss once this threshold is crossed it leads to a catabolic crisis