Cartilage relies on diffusion for nutrition and chondrocytes have limited capacity to repair extracellular matrix under substantial load.

“but chondrocytes that the con the cartilage itself is avascular it gets its nutrition through diffusion from joints and they're not very efficient at making The extracellular Matrix which is imperative so if there is any un if there's overload of the cartilage the chondrocytes will respond and sometimes they die sometimes they go into senescence”