The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
we now believe that age related muscle loss is not I mean it's a demographic but it's not a physiological process of a slow decline in muscle we now believe it's short successive periods of reduced physical activity that are actually experienced after which they don't fully regain their muscle
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and the decline starts somewhat slowly and by about the seventh decade starts to accelerate by the seventh decade uh Pardon Me by the 8th decade when a person is in their 70s the decline is so rapid that it appears almost irreversible
it is not a continuous slope of decline that reflects some physiologic process within the roping muscle but instead it's a series of discret declines each one precipitated by a period of inactivity
we have long looked at data and there is an unambiguous and clear decline in spontaneous activity deliberate activity and lean mass in the Aging individual
we now believe that AG related muscle loss is not I mean it's a demographic but it's not a physiological process of a slow decline in muscle we now believe it's short successive periods of reduced physical activity that are actually experienced after which they don't fully regain their muscle and that adds up in the last two decades of life and that seems to be contributing to the muscle loss that we see in those demographics
there is an unambiguous and clear decline in spontaneous activity deliberate activity and lean mass in the Aging individual and the decline starts somewhat slowly and by about the seventh decade starts to accelerate by the seventh decade uh Pardon Me by the e8th decade when a person is in their 70s the decline is so rapid that it appears almost irreversible
it's actually a graded step function so again if you're watching me this is easier to see it's you know here's your muscle mass and then boom a big drop and then you stay there for a little while and then boom a big drop and Away you go and Away you go and he said what it really comes down to the individual level is a series of discreet periods of inactivity that result in sudden relatively speaking meaning over a period of months or weeks big drops in muscle mass that are never recovered
but if you actually look at it at the individual level that's not at all what it looks like it's actually a graded step function so again if you're watching me this is easier to see it's you know here's your muscle mass and then boom a big drop and then you stay there for a little while and then boom a big drop and Away you go and Away you go and he said what it really comes down to the individual level is a series of discreet periods of inactivity that result in sudden relatively speaking meaning over a period of months or weeks big drops in muscle mass that are never recovered
when you look at spontaneous activity and movement of people as they age you see a very similar pattern which is a relative Plateau preservation of not just activity but lean mass followed by a deterioration suggesting that as lean mass goes down movement goes down activity goes down and that then it feeds back on itself it becomes a vicious cycle