Anabolic resistance in older adults is primarily caused by physical inactivity rather than aging itself.

“you can take an aged individual who might have you know again 20 or 30% less anabolic response to protein than a young person but if you exercise them you can bring them up to the same level as a younger person”

“these two factors suggest that activity might be the main determinant of anabolic resistance and an aging individual or age within an individual is simply a proxy for activity”

“the same amount of protein that was ingested did not lead to the same amount of protein synthesis”

“and I can normalize for age by physical activity”

“if I take an older person and I do some exercise and I give protein I see a completely normal response”

“these two factors suggest that activity might be the main determinant of anabolic resistance and an aging individual or age within an individual is simply a proxy for activity”

“and with the intrinsic protein we could show that less of the ingested protein was converted to muscle so that is also an resistance in a more single meal like type of approach”

“They had to double that amount of protein. Okay? So, um, and that's because again, you need it's just your your muscle tissue is not as sensitive to the amino acids.”

“now to your point about physical activity being the major driver here, it's I think that's 100% I agree. think it's totally true and there's so much evidence out there to to prove that Luke Vanlon's study being one, but also older adults that do engage in resistance training have the same anabolic response to the same amount of protein as younger adults.”

“That's because muscles become less sensitive to amino acids in response to protein intake, a phenomenon known as anabolic resistance. Most people think this is due to aging, but physical inactivity is the real culprit.”

“Older adults who stay physically active or who engage in resistance exercise right before consuming protein don't experience anabolic resistance. Their anabolic response is identical to that of younger adults.”

“older adults experience something called anabolic resistance so their skeletal muscle is not as sensitive to amino acids to make so uh to to increase skeletal muscle protein synthesis”

“one of the strongest things that increases the sensitivity to food intake is physical activity now if you provide if you give an older person an exercise session before food intake their response is almost completely normal so much of the responsiveness the anabolic resistance can be overcome by physical activity”

“exercise makes muscle more sensitive to protein and essentially negates anabolic resistance when older adults exercise before protein intake their muscle anabolic response is identical to that of a younger adult”