The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
So we did a study with lipopolysaccharide, LPS. So LPS causes massive, you know, muscle wasting and sarcopenia with time. And in that model too, the ketones are protective in some ways by inhibiting some of the anti-inflammatory...inhibiting the inflammatory effects of LPS.
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And we're sort of wasting away in the context of a weight loss diet or in the context of intermittent fasting. So then the ketones come into play when we're in a calorie deficit like I said, but also when we're doing time-restricted feeding, I think the ketones provide an anti-catabolic effect. But from our perspective, we're super interested in ketones preventing age-related sarcopenia, skeletal muscle wasting associated with cancer cachexia. I think that's important. And they're doing it I think not only providing in the context of a disease phenotype or a chronic aging phenotype, the alternative energy function is there, but the anti-inflammatory effects, I think.
So, the ketones then work through anti-inflammatory pathways that can mitigate the inflammation-induced muscle wasting associate.