Ketones can mitigate inflammation-induced muscle wasting by inhibiting inflammatory pathways, such as those elevated by IL-1 beta and TNF alpha in cachexia.

“And we're sort of wasting away in the context of a weight loss diet or in the context of intermittent fasting. So then the ketones come into play when we're in a calorie deficit like I said, but also when we're doing time-restricted feeding, I think the ketones provide an anti-catabolic effect. But from our perspective, we're super interested in ketones preventing age-related sarcopenia, skeletal muscle wasting associated with cancer cachexia. I think that's important. And they're doing it I think not only providing in the context of a disease phenotype or a chronic aging phenotype, the alternative energy function is there, but the anti-inflammatory effects, I think.”