Muscle cells are multinucleated and contain satellite cells that contribute DNA to the muscle fiber, determining the potential size of the muscle.

“we think the reason is is that each myonuclei can only control protein synthesis for a certain area so you can only get the muscle fiber can only grow as big as it has myonuclei”

“there used to be a thing that we referred to as a myonuclear domain limitation so in other words a cell would only grow so this would be your fiber it would only hypertrophy or grow in diameter to the extent at which the nuclei could control it and so in order to gain more growth you actually have to get more satellite cells to come in and add nuclei”