there's definitely an antidepressant effect that seems to correlate with biomarkers of the immune system so so the more potent the il-6 response the more potent the antidepressant response
The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
there's definitely an antidepressant effect that seems to correlate with biomarkers of the immune system so so the more potent the il-6 response the more potent the antidepressant response
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
recently there was a study looking by dr. charles Rosen he had made this like fancy contraption where he elevated core body temperature and he had a sham control so actually people the Sham control also made people a little bit hot and they thought they were actually getting the treatment but it had a very strong antidepressant
I personally feel very optimistic about deliberate heat exposure having a possible role as a non-pharmacological intervention for depression.
This preliminary study paves the way for exploring whole-body hyperthermia, using saunas, as a promising tool to combat depression.
Deliberate heat exposure may be a promising therapeutic avenue for the treatment of depression.
how whole body hyperthermia (ie. sauna, hot bath, steam room, hot yoga) may improve depressive symptoms.
Deliberate heat exposure using sauna and hot tubs is a potent tool for mood and depression symptoms.
It’s astounding, the number of cultures in the world that use phasic exposure to high heat for healing purposes, or for transcendent purposes. I mean, we’re sitting in the new world, and certainly, the use of things like sweat lodges, and Temazcals were just were rampant in new world indigenous cultures, but across the old world too, you know. If you look at the healing rites in the ancient world, you know, hot baths were just a huge part. So it’s a widespread human thing. All around the globe, so many groups recognized, you know, it’s not just living in a chronically hot environment, it’s this outrageous heat for a time limited basis, right? I mean, why would you repeatedly stuff yourself in a smoky, hideous, dark, miserable, sweat lodge right? Answer, because that’s what sort of face heated exposure induces profound states of positive wellbeing that have antidepressants effects, right?
So, you know, whether it’s through the exercise or the hot yoga, or the sauna, or the hot bath, or the steam shower.
But if we're able to actually capitalize on sauna, if people are more open to using whole-body heating practices, then maybe we have an avenue in to get at some of those biological pathways that exercise is triggering, like you just described.
Would people rather, you know, take drugs that maybe aren't working so well, or maybe come with a certain number of side effects, or say, "Oh, once a week, I have to sit in this thing for 45 minutes and read a magazine," right?
Yeah, absolutely. I think the pathway is totally plausible.
there's been a sham-controlled trial looking at the effects of heat stress on major depressive disorder. There was a sham-controlled. And basically, it had an antidepressant effect. And I'm working now. I'm collaborating with someone. I'm a small collaborator. I'm the biomarker person. But Dr. Ashley Mason, she's at UCSF. She's now running more large randomized control trial on this.
4–7 sauna sessions per week, 20 minutes at 80°C+, reduce cardiovascular mortality risk by 40% over a decade.
Regular sauna use raises BDNF and improves verbal memory in older adults.
Sauna protocols only generate the longevity effect when sessions exceed 30 minutes.
Hot-tub bathing yields cardiovascular benefits comparable to traditional Finnish sauna at matched core-temp dose.