The Minnesota Coronary Experiment showed replacing saturated fat with linoleic acid lowered serum cholesterol but did not reduce death risk from coronary heart disease or all causes.

“So let's let's let's kind of start with the Minnesota Heart Study. Okay, so I've talked about the Minnesota Heart Study before. Um, this is a study that took place in the 1960s. I believe it ran 7 yearsish. Um, it's notable because it was carried out in an environment that would be very difficult to do today. It's very difficult to do long-term nutritional studies with complete control over what your subjects eat. And yet that is essentially what this study was able to do because it was carried out in institutionalized patients. So these were mentally institutionalized patients. They were inatients in a hospital and the experimental design was quite elegant which is the subjects were divided into two groups. One group was uh given a diet that was higher in saturated fat. The other group was given a diet that was lower in saturated fat but had an isocaloric substitution of polyunsaturated fat. Now I believe it was mostly linoleic acid that made the the substitution. So in”