Paul Saladino· MD
4-HNE is when you oxidize a linoleic acid molecule it breaks in half and that's half of it right HNA now HNE is a great marker of the negative health effects of linoleic acid because it's only produced from linoleic acid
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
4-HNE is when you oxidize a linoleic acid molecule it breaks in half and that's half of it right HNA now HNE is a great marker of the negative health effects of linoleic acid because it's only produced from linoleic acid
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it's an 18 carbon omega-6 polyunsaturated fatty acid that evolutionarily humans would have only had a small amount of because it's only found in nuts and seeds and we're only going to get nuts and seeds occasionally probably as survival Foods mostly in the fall before we're going to get into winter so in Northern latitudes the hypothesis that I've come up with and I think other people have come up with is that perhaps as humans as we moved away from the equator during the fall time we were eating more of these foods to fatten up a little bit you get more linoleic acid that can be an obesogenic food for humans and we know that more of this linoleic acid which is present in huge amounts in seed oils equals more hne in the human body