The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
on the road to 50 divisions the cells that make us up will encounter some form of stress they cannot resolve they will pull an emergency break and they will stop dividing forever and we call this state when you do this we call cells I do this a senescent is cell
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So we now, we meaning the field now I think, would agree that senescence can best be understood as a stress response. It's the way cells have evolved a program to respond to certain types of stressors. And the result of that response, that stress response is twofold. The first is that cells will lose the ability to divide, essentially irreversibly. So what happens is tissues begin to accumulate stress cells that can no longer divide. The curious thing is that they also tend not to die, or they don't very easily die so they accumulate with age.