Rhonda Patrick· PhD
The other part of that stress response is the cells turn on a program that causes them to secrete molecules that we classify as being bioactive. And the reason why that term is vague is because there are probably 50, 60, maybe 70 molecules that these cells begin to secrete and so they have many, many activities. Some of them are attract the immune system, so they're cytokines and chemokines that are immune attractants. Some of them are growth factors that will alert the neighboring cells, because maybe now if you have a need for proliferation the senescence cell itself cannot divide, but it may want to tell its neighbors, "Hey, start dividing." They secrete proteases that remodel the tissue that would also help with regeneration and repair. And they also, now we know very new data from our lab, they secrete bioactive lipids like prostaglandins and leukotrienes, which are very important for modulating inflammation fibrosis but also, again, tissue repair.