So you've got a group of cells in the basal forebrain that use glutamine to activate the cortex. You've got a group of neurons in the dorsal raphe, which is a part of the brain that produces all sertogonergic cells or serotonin producing cells that is activating the cortex. You've got an area in the locus coeruleus...you could name a bunch of these that are all involved in activating the cortex, and those are orchestrated, or basically they're coordinated by one group in the area called the hypothalamus, that produces hypocretin cells.