The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
So we did a highfat study with spermadine and and we we showed that in old animals spermadine could suppress the metabolic uh dysfunction that came from highfat diet in mice. But we had some control mice too and actually not many but the because the design the study wasn't designed to do lifespan but we left them alive and looked at survival and the spermine extended the lifespan of the mice too.
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
And in mice, you actually can give a combination of high-fat diets, that usually would cause obesity, with spermidine to reduce weight gain through mechanisms that we don't understand and that we believe to be autophagy-dependent but have to elucidate in some molecular detail.