Paul Saladino· MD
anyone on a statin who gets septic is gonna be in a world of hurt because they have less lvo to take care of those bacterial products
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
anyone on a statin who gets septic is gonna be in a world of hurt because they have less lvo to take care of those bacterial products
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now they just said trauma or critical illness in this abstract i editorialized statins and i think that if we do more research i have certainly observed this anecdotally and the people that i've worked with in my friends and my family and i believe there is research showing that lowering the ldl particles too low will be associated with increased incidence of bacterial pneumonia or other infections in humans
the key takeaway from that study was that hypolipidemia trauma critical illness also potentially from statins could predispose people to bacterial pneumonia and other infectious consequences because ldl has a valuable immune role in the human body