Bempedoic acid has less muscle soreness than placebo but not zero, and is more hepatoselective than rosuvastatin.

“but it's you know and they did comparative trials versus a statin versus placebo and there is definitely less with it or so but it's not going to be zero so it's worth a trial if you're really hung up”

“the cool thing is because one of our biggest downsides to statin is people get these myopathic symptoms be they weakness muscle aches or whatever you know that it's a big problem with statin therapy probably more prevalent than what clinical trials would show us but this bempedoic acid does not have any uptake in the muscle cells there's a specific receptor that pulls it into the liver so it is hepatoselective”

“uh is a drug called bidic acid that is a prodrug so it's a very elegant drug uh it's taken as a pill uh but it's ineffective until it's metabolized by the liver and in the liver it then inhibits um cholesterol synthesis what makes this drug special is unlike statins this drug only works in the liver so statins work throughout the body they do most of their work in the liver but technically every cell is impacted by a Statin only hepatocytes are impacted by bondic acid and it lowers apob same way lowers cholesterol synthesis liver says I need more cholesterol puts more LDL receptors up pulls more LDL in LDL and cholesterol go down but no side effects no type to diabetes risk nothing nothing it's just it's only acting in the liver”