Simvastatin has been largely removed from the market due to pharmacokinetic issues and a high potential for drug-drug interactions, unlike atorvastatin and rosuvastatin.

“so they get in the other drugs are not as hydrophilic so the only way they get into liver is various receptors pulling and there's a whole variety of transporters that pull molecules into the liver but they're subject to interference what a ton of other drugs that may be in your system or other molecules so you don't have the clean pharmacokinetics like you do with pravastatin or Razoo the statin”

“tend 80 milligrams of Simba's been taken off the market actually quite high was well because of a variety of Pharma kinetic reasons has a ton of drug drug interactions and we're in a polypharmacy world whereas there's far less with a torva and infinitely less with resumed statin”