High-dose statins are generally not necessary today, as most ApoB lowering and LDL receptor upregulation occurs with the lowest effective doses.

“I don't believe any patient needs to be on a mega dose of a Statin today because um we just have too many other tools”

“I don't believe any patient needs to be on a mega do of a Statin today because we just have too many other tools”

“I do have some concern about Mega do of statins because one the efficacy curves show that Statin hit their maximum efficacy at about quarter dose like the the curve for the efficacy of a Statin looks like this right so you know for example if you look at Rua Statin you're getting 85% of its maximum APO reduction at 5 milligrams 80 roughly 85% of you hit you hit the maximum and by the way it's a drug that is typically dosed up to 40 milligrams so once you hit 10 milligrams there's no need to go any higher because all you're really doing is buying side effects and you're getting very little in the way of increased efficacy”

“we don't use them we're not treating acute coronary syndrome patients where maybe you want to be on a high dose Statin for x amount of time you can get most of the apal B lowering with a Statin with the baby dose this has been proven in trial after trial most of the LDL receptor upregulation occurs with the lowest dose that inhibits cholesterol synthesis”