Peter Attia· MD
so the combination of those three drugs uh will will keep my APO B negligible and more importantly or at least I would say equally importantly there are no side effects associated with that for me personally and again when it comes to lipid management it's certainly one of my favorite topics I always tell patients we have tools today that we couldn't even fathom 20 years ago 20 years ago if you needed to have your APO B slammed there was only one way to do it which was Mega dose of statins I don't believe any patient needs to be on a mega dose of a Statin today because um we just have too many other tools and I do have some concern about Mega dose of statins because one the efficacy curves show that statins hit their maximum efficacy at about quarter dose like the the curve for the efficacy of a Statin looks like this right so you know for example if you look at reservastatin you're getting 85 of its maximum apob reduction at five milligrams 80 roughly 85 percent of you hit you hit the maximum and by the way it's a drug that