Statins can have widespread adverse effects on muscle metabolism over time. — Whalespan
Statins can have widespread adverse effects on muscle metabolism over time.
⚠ High risk
We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
✕NOTSUPPORTED
⚠
High-risk intervention — consult a physician before acting.Drug-drug interactions, dose-dependence, and screening contraindications apply.
“Some of those adverse effects, people tend to minimize because the benefits for high-risk patients are so evident from the clinical trials. But as you look at the data, there are some pretty surprisingly adverse things that are out there that are a little bit below the radar screen. One of them is muscle effects, which surely have been recognized. People tend to think about them in the more extreme case where people get muscle damage and life-threatening complications of muscle breakdown. That's very rare, fortunately. Otherwise, statins wouldn't be out there in the way they are. But we and others need to develop evidence that there may be effects on muscle metabolism that might be much more widespread that could accumulate over time in a way that may not be manifested in an obvious symptom, but could lead to changes in muscle function, muscle strength.”
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