Paul Saladino· MD
the third step is HMG COA reductase this is where statins are Inhibitors and hmd COA reductase makes mevalonate it's called the mevalonate pathway
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
the third step is HMG COA reductase this is where statins are Inhibitors and hmd COA reductase makes mevalonate it's called the mevalonate pathway
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Statins happen to inhibit what's called the rate limiting enzyme it's the third step in the cholesterol synthesis pathway and of course that's modulated by the enzyme hmg coa reductase statins pretty significantly in a dose-dependent fashion inhibit that enzyme so you can seriously slow down cholesterol synthesis in various cells