An LDL cholesterol level of 190 mg/dL or greater generally indicates genetic abnormalities and warrants consideration for statin therapy.

“If your LDL is 190 and greater, the particle measurement probably isn't going to affect the treatment decision because in almost all cases, those patients have genetic abnormalities. ApoE may be part of it, but not the cause of those very high levels, that's usually an LDL receptor abnormality. Those patients are at, sufficiently, a high life-long risk of heart disease that they are candidates for statin therapy almost in all cases.”