Blocking cholesterol synthesis with statins or lowering LDL-C with PCSK9 inhibitors can impair hormone production due to insufficient cholesterol. — Whalespan
Blocking cholesterol synthesis with statins or lowering LDL-C with PCSK9 inhibitors can impair hormone production due to insufficient cholesterol.
⚠ High risk
We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
✕NOTSUPPORTED
⚠
High-risk intervention — consult a physician before acting.Drug-drug interactions, dose-dependence, and screening contraindications apply.
“well and you know the good thing is that our liver can make cholesterol but the real problem lies when you start putting in a statin or you know something that blocks the cholesterol synthesis pathway by blocking hmg coe reductase or or you push ldl so low with something like a pcsk9 inhibitor that there's no ldl moving around your body or it's gone so low that you just can't make your hormones”
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“the real problem lies when you start putting in a statin or you know something that blocks the cholesterol synthesis pathway by blocking hmg coe reductase or or you push ldl so low with something like a pcsk9 inhibitor that there's no ldl moving around your body or it's gone so low that you just can't make your hormones”