Statin trials published before 2004 showed significant improvements in cardiovascular event ratios for both secondary and primary prevention based on LDL levels.

“after 2004 graphic looks like this and you can see here that these lines do not slope down Le nearly as sharply as the lines from pre 2004 in fact some of these lines even go up meaning that when you lowered LDL in some of these trials like the C's trial like enhance which was looking at uh intimal medial thickness getting worse uh this is JY HF which was all cause death as the outcome which got worse when you lowered LDL”