Paul Saladino· MD
mechanistically though some small trials that have gotten attention this one only had 18 subjects which is a pretty small number six weeks withdraw phase of Statin six week re challenge they found an improvement in cognition with this continuation of statins and worsening with re challenge they say statins May adversely affect cognition in patients with dementia but it's important to note that metaanalysis of observational studies um doesn't show any effect on memory and there is some signal that they may even have a neuroprotective effect statens do