Peter Attia· MD
i think virtually all of the statins contribution to atherosclerosis reduction is april b reduction
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
i think virtually all of the statins contribution to atherosclerosis reduction is april b reduction
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disease and statins lower apo b particle number that's how they work fewer apob particles in plasma fewer get into the arterial wall fewer get trapped it's not that complicated
we can get most of the apob B lowering with a Statin with the baby dose this has been proven in trial after trial most of the LDL receptor upregulation occurs with the lowest dose that inhibits cholesterol synthesis
So statins tend to work primarily on the larger cholesterol-rich LDL particles and the lowering of LDL cholesterol by statins is more strongly related to that effect than the effect on smaller LDL, which are cholesterol-depleted.