We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
since 2008 the clinical trials that have been done to show a benefit of LDL reduction have been very muted the degree of benefit is even smaller 0.3% in large number of patients so really the robustness of statin data is not very good
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
the evidence from starting trials that it is conflicting that there is no dose response by dose response I mean that if you lower LDL to a small degree you should get a little benefit but if you lower it to a large degree you should get a bigger benefit there should be consistency across the trials