Overly suppressing cholesterol synthesis, particularly with statins, may pose a risk at the individual level. — Whalespan
Overly suppressing cholesterol synthesis, particularly with statins, may pose a risk at the individual level.
⚠ High risk
We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
✕NOTSUPPORTED
⚠
High-risk intervention — consult a physician before acting.Drug-drug interactions, dose-dependence, and screening contraindications apply.
“I do have some concern about overly suppressing cholesterol synthesis which is typically an issue in patients who are taking statins if you over suppress cholesterol synthesis I think an aggregate there's a meaning at the population level this does not seem to pose a problem but at the individual level I would exercise some caution and so the dis master all becomes a guidepost”
“there's gonna be a subset of patients in which you go too far these are patients who don't synthesize a boatload of cholesterol they're probably hypo synthesisers to begin with and you statin i's the hell out of them and you are increasing their susceptibility”
“if you over suppress cholesterol synthesis I think an aggregate there's meaning at the population level this does not seem to pose a problem but at the individual level I would exercise some caution”