Paul Saladino· MD
when you get mitochondrial dysfunction you become insulin-resistant that is how it works we are creating insulin resistance with statins
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
when you get mitochondrial dysfunction you become insulin-resistant that is how it works we are creating insulin resistance with statins
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So, I don't think it's very surprising that statins could increase insulin resistance because they're negatively affecting our ability to make energy in the mitochondria. And ultimately, I think insulin resistance is mitochondrial failure. And that term gets thrown around a lot, but if we really distill, and let me know if you agree with this, if we really distill mitochondrial dysfunction, what is that? I think that's failure of adequate or efficient energy production at the level of mitochondria.