Statin observed risk reduction is less than that seen in Mendelian randomization studies.

“But why is it that in the MR study which in theory would be the most pure study every mill or every roughly 40 milligrams per deciliter reduction in LDL cholesterol is giving you 50 to 55% reduction but when you do the same thing with a statin you you still get a benefit and that benefit appears non-ending but it's only 22%. Doesn't that tell us that statins are bad?”