Sulforaphane at 1 mg/kg/day reversed depressive symptoms in mice induced with inflammation by lipopolysaccharide.

“And there's also some very interesting animal modeling in schizophrenia, some from the same group. So, yeah, I mean, I think all signposts are pointing in the direction... [Rhonda]: That's cool. There's definitely a common denominator with oxidative stress and inflammation in both autism and schizophrenia, but also in depression. And this is another brain dysfunction, I guess, if you want to call it that, but inflammation has been shown now to play, actually, a major causal role in depression. And there's been some animals studies that you may have seen where the sulforaphane, broccoli sprout extract in sulforaphane has shown to be even as good as fluoxetine, which is Prozac, in alleviating, like, all these different methods of stress they have to make an animal depressed, and then they give it Prozac or broccoli sprout extract and it works just as well, which is extremely interesting.”

“And that is that that NRF2 may be a good target for novel anti-depressant drugs, but also because they're inducing depression through inflammation.”

“Mice given lipopolysaccharide to induce an inflammatory response experience depressive symptoms just like humans do. However, taking these same mice and giving them a whopping 1 milligram per kilogram of body weight a day of sulfurophane reverses these depressive symptoms.”

“A variety of stressors can do that. social stress, messing with the circadian rhythm, water deprivation in 10 different models of stress induced depression. Sulurophane alleviated depressive symptoms and anxiety as well as the anti-depressant Prozac in mice.”

“Sulurophane also decreased stress hormones and the inflammatory response in response to various social stressors indicating that the neuroprotective effects on depression and anxiety may be associated with lower inflammation and lower stress hormones in this case as well.”