Many forms of oral butyrate supplements administer large doses not targeted to the colon, unlike pro-butyrate which uses a fiber matrix for slow release in the colon.

“there's a lot of forms of butyrate on the market that are like sodium butyrate calcium magnesium butyrate which are producing which are uh administering a large dose of butyrate and not targeted to the colon where it should be so i'm i'm a big fan of pro-butyrate which is a it's it's actually complex in a little bit of a fiber matrix but it's intended to make its way to the colon and then be more of a slow release so it's more of a physiologic dose it gets to the cold it actually gets to the colon”