In older men with suboptimal health on testosterone replacement therapy (TRT), cardiovascular disease risk was higher in the first year, equal at three years, and lower than placebo at five years.

“there was a study I shouldn't say similar there was a parallel study to this idea published I want to say it was in JAMA but it might have been the England Journal of Medicine a few years ago that looked at men with older men who were not particularly healthy put on testosterone replacement therapy and one year after the study the men on the testosterone group had a higher incidence of cardiovascular disease three years after the study initiated the risk was equal and at five years the men receiving testosterone had a lower risk of heart disease than the men on the placebo”