Topical testosterone was withdrawn from the FDA approval process due to a lack of long-term safety data, not efficacy.

“so we could say at least two dozen you know um the numbers like depending on how you look at the indication whether it's for you know hypogonadism versus sexual dysfunction you know this right 25 right let's just say those products get approved on biochemical efficacy do they or do they not raise testosterone they're they're not yeah and also outcome like the outcome of design you know that you're looking for the Target outcome of the study but the point is they they don't require the 5year safety window because we've already established over decades that exogenous testosterone at physiologic doses is safe is safe yeah”