High SHBG can be associated with hyperthyroidism, anorexia, alcoholic cirrhosis, primary biliary cirrhosis, hypogonadism, and testosterone replacement therapy; low SHBG can be associated with hypothyroidism, sleep apnea, insulin resistance, diabetes, and growth hormone-secreting tumors.

“I think I reversed it high shbg is hyperthyroid low shbg is hypothyroid low SHBG the differential diagnosis also includes sleep apnea insulin resistance like we said hypothyroid diabetes and other conditions like chromatically which is a growth hormone secreting tumor can cause that high SHBG we think of anorexia alcoholic cirrhosis hyper thyroid primary biliary cirrhosis low gonads hypogonadism and assassin replacement therapy can create a high shbg”