When exogenous hormones like testosterone are administered, the natural pulsatile hormonal production and its regulatory feedback mechanisms are eliminated, leading to fluctuations that can create a free androgen-dominant environment.

“because you have a long Ester compound in your system you don't have the luxury of endogenous manipulation of your hormones going up when you need them and down when you need them like the pulsatile framework of your natural production is non-existent you're just like getting a big spike whenever you inject and then it's slowly going to diminish out of your system until you want to inject again and a lot of guys even when they're doing you know twice a week or something you're still getting like some level of Spike and then dips and then Spike and dips where if you were a natural with normal natural testosterone production it would be like very pulsatile with a dial rhythm with natural dips and valleys and Peaks and it would not fluctuate where it's like Bam Bam”