The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
testosterone is mostly bound so just as I discussed with cortisol most cortisol is bound so is most testosterone it's primarily bound to two hormones sex hormone binding globulin or shbg and albumin but a relatively small amount and it depends on how much albumin and shpg you have remains free so we call that free or Unbound testosterone and it's anywhere from one to three percent of the total testosterone
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
So if a person's total testosterone is 800 nanogs per deciliter, um most of that is bound and sex from binding globulin and albamin probably do the lion's share of binding. Um, and if a guy's got 2% of that as free or unbound, that would translate to 16 nanogs per deciliter of free testosterone.
Um and these binding proteins SHBG and albumin comprise the vast majority of testosterone. Um I think SHBG is about 60% of your total tea will be bound by SHBG and then like 38% is albumin and then 2% to 3% roughly depending on how much SHPG produced and some other factors is actually free testosterone.