Peter Attia· MD
when you have enough testosterone available what tends to happen is the androgen receptors upregulate to meet the demand for metabolizing that testosterone and that the kind of the regulation of the excess testosterone think about the negative feedback loop functions more so on like luteinizing hormone and and the good ads and that sort of thing right yeah so i i if i had to hazard a guess that would be my guess that the the regulation in terms of trying to tamp that down because think about if you're not getting exogenous testosterone if you're not getting exogenous testosterone then there's probably not that same negative feedback regulation loop and so i always hate it when people go well it makes sense because there's tons of stuff in metabolism you say well it makes sense that it ends up not working out in the study but to me it would make sense that the muscle might increase its androgen receptor density to meet that testosterone load or that free testosterone load so long as you're not having so much testosterone that's not negatively feeding back to the gonads and limit or reducing luteinizing hormone or increase increasing aromatization those sorts of things