The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
what you see sometimes is that you give a patient T4 and they start to feel worse and sometimes their TSH actually improves and the reason it improves is T4 does have some inhibition of TSH not as much as T3 but some but what if for physiologic reasons their D1 and D2 are being down regulated while their D3 is being upregulated and they're taking that T4 that you're giving them and they're just making more and more reverse T3
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
a person who has low grade inflammation these are typically things that we we might see drive that state and that patient even though their TSH improves doesn't necessarily feel better
what you see sometimes is that you give a patient T4 and they start to feel worse and sometimes their TSH actually improves and the reason it improves is T4 does have some inhibition of TSH not as much as T3 but some but what if for physiologic reasons their D1 and D2 are being down regulated while their D3 is being upregulated and they're taking that T4 that you're giving them and they're just making more and more reverse T3