Time-restricted feeding enhances proteostasis, specifically the folding of cytoskeletal proteins by the ATP-dependent chaperonin complex (CCT).

“Second thing that we found is proteostasis of protein folding is necessary and in many other organisms people have shown that in different components of protein folding machinery. But here, what we found is there is a new protein folding, a very newly-identified folding machinery called ATP-dependent. It's a chaperonin complex. Eight different components form this barrel-like structure to fold proteins. And this requires energy, and that CCT component has been shown to be important for various muscle, sorry, various cytoskeletal protein folding, and it make sense for heart.”